Influenza Adrift: Rethinking Hemagglutinin Antigenic Evolution
نویسندگان
چکیده
منابع مشابه
Influenza Adrift: Rethinking Hemagglutinin Antigenic Evolution
s S5 modulate antigenicity and receptor binding, confounds retrospective analysis of genetic variation in HA. The situation is complicated further by the occurrence of epistatic changes within HA and between HA and NA to maximizeviral fitness following selection. Moreover, substitutions selected to modulate receptor avidity will inevitably modify receptor specificity for various sialic acid ter...
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The HA1 domain of HA, the major antigenic protein of influenza A viruses, contains all of the antigenic sites of HA and is under continual immune-driven selection. To resolve controversies on whether only a few or many residue sites of HA1 have undergone positive selection, whether positive selection at HA1 is continual or punctuated, and whether antigenic change is punctuated, we introduce an ...
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11 We have carried out a comprehensive analysis of the determinants of human influenza A H3 12 hemagglutinin evolution, considering three distinct predictors of evolutionary variation at in13 dividual sites: solvent accessibility (as a proxy for protein fold stability and/or conservation), 14 experimental epitope sites (as a proxy for host immune bias), and proximity to the receptor15 binding r...
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ژورنال
عنوان ژورنال: Osong Public Health and Research Perspectives
سال: 2011
ISSN: 2210-9099
DOI: 10.1016/j.phrp.2011.11.021